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Microsoft Office 2016 helps you to do your best work - anywhere, anytime and with anyone. New, modern versions of the classic desktop applications, Word, Excel. Microsoft Word is more than just Word Processing Software. Discover new ways to work together and share documents online. Try or Buy for Home or Business. · It's many years since I have heard of this one!! Word has a "Read Only Recommended" mode. If you set it for a document, it will always save the document that way. [Fix] Microsoft Word Always Shows “[Compatibility Mode]” Text in Titlebar - Recently an AskVG reader "Prajwal" contacted me regarding an strange problem in. By 1. 99. 3 it was generating 5. Clearly there was something extraordinary about Word for Windows. Part of its success was due to Microsoft’s marketing acumen. But it was also a stunning technical achievement, and its ability to run on ordinary PCs created the first popular vanguard of the new graphics- oriented style of document preparation. Remember, this was a time when a typical personal computer might have an 8 Mhz processor, 1 megabyte of memory, a 2. How did Word accomplish so much with so little? There’s only one way to understand the magic in detail: read the code. With the permission of Microsoft Corporation, the Computer History Museum is pleased to make available, for non- commercial use, the source code of Word for Windows version 1. January 1. 0, 1. 99. This material is © Copyright by Microsoft. The 7 MB zip file contains 1. In the root directory there is a “readme” file that briefly explains the rest of the contents. Most of it is source code in C, but there are also text documents, x. To access this material you must agree to the terms of the license displayed here, which permits only non- commercial use and does not give you the right to license it to third parties by posting copies elsewhere on the web. Download Microsoft Word for Windows Version 1. Source Code. Other historical source code releases in this series include IBM’s APL programming language, Apple II DOS, Adobe’s Photoshop, Apple Macpaint/Quick. Draw, and Microsoft’s MSDOS. If you would like us to do more of this, please consider supporting the museum’s efforts by making a donation. We are a 5. 01(c)3 non- profit organization. How Microsoft Word Came To Be. In the dark ages of computer word processing, what you wrote (and saw on the screen, if you had one) was cryptic formatting commands embedded within the text, like this. Main Street. Morristown, NJ 0. I just wanted to drop you a note to thank you…After “compiling” and printing, you finally saw the result – which often wasn’t what you wanted. Make changes. Try again. The emergence of WYSIWYG (“What You See Is What You Get”) word processors changed all that. The screen showed what the final document would look like, and keyboard commands you used changed the look of the text, not a programming script. Charles Simonyi at Xerox PARC in 1. One of the first such programs was BRAVO, created in 1. Butler Lampson, Charles Simonyi and others at Xerox PARC, the Palo Alto Research Center, for the groundbreaking Alto computer. Simonyi later said,It was clear that quite a beautiful editor could be written for the Alto. Remember, the Alto had a black and white bitmap display. It had a mouse. It had an un- decoded keyboard. It had all the ingredients that are necessary for WYSIWYG. And, of course, then the network came around. The laser printer was coming alive. So all the components were there, except for the software…. We set out to write an editor and we finished it about three months. Like much of the other innovative Alto software and hardware, BRAVO was never sold as a commercial product. After nine years, Simonyi was frustrated by Xerox’s inability to turn great ideas into products. I lost faith in Xerox’s ability to do anything”[3] . In 1. 98. 1 he left and joined Microsoft to lead a team in creating application programs. The first, already in progress when he arrived, was the spreadsheet Multiplan, a Visi. Calc competitor. Simonyi was well- suited from his Xerox experience for the next assault on the competition: to unseat Micro. Pro’s popular Word. Star word processor. He hired Richard Brodie, a brilliant programmer he had first hired in 1. PARC. The fact that Brodie had no college degree wasn’t an issue; Brodie said later that “He asked me some programming questions and he liked the way I answered them.”[4]In the summer of 1. Brodie began working with others at Microsoft on a word processor to be controlled by a mouse. It was finished just over a year later, in October 1. I had pretty much a free hand. It was a pretty small program, and I was familiar with word processing from my work at Xerox PARC with Charles.”[5]It may have been a “small program” but it had some sophisticated features, including support for style sheets, multiple windows, footnotes, mail- merge, undo, and the proportional fonts that the newly emerging laser printers would be able to use. Microsoft founder and president Bill Gates was impressed. One thing that just blew Bill away was an optimization of the display speed. We actually formatted as you typed. Every time you inserted one character, the screen would update to show exactly what was going to be printed.”[6]Free demonstration copies of Microsoft Word for MS- DOS were bundled with the November 1. PC World magazine. But it received mixed reviews, in large part because it was so different from what most people were used to. The 1. 98. 4 BYTE magazine review said it was “clever, put together well, and performs some extraordinary feats” but “extremely frustrating to learn and operate efficiently. Word’s developers seem to be trying to completely reinvent word processing.”[7]That is precisely what they were trying to do. Although it was inspired by the earlier work at Xerox, few people outside the research community had been yet exposed to the new regime that would eventually predominate. Microsoft Word brought WYSIWYG to the masses. Over the next years Word was continually improved. The first version for Microsoft Windows was released in late 1. It received a glowing review in Inforworld [8] that didn’t flinch at the price: “If your system is powerful enough to support Microsoft Windows, at $4. Version 1. 1a, whose source code we are making available here, was released the next year. Microsoft Word For Windows had started its remarkable climb to 9. Acknowledgement. We are grateful to Roy Levin, Managing Director of Microsoft Research, Silicon Valley, for working hard to find the source code and getting permission for us to release it. References[1] Stan Liebowitz and Stephen Margolis, “Winners, Losers, and Microsoft: Competition and Antitrust in High Technology”, Independent Institute, 2. Oral history interview of Charles Simonyi by Grady Booch, February 6, 2. Quoted in James Wallace and Jim Erikson, “Hard Drive: Bill Gates and the Making of the Microsoft Empire”, Harper. Business 1. 99. 2, p 2. Quoted in Cheryl Tsang, “Microsoft; First Generation”, Wiley & Sons, 2. Ibid, p. 5. 7[6] Ibid, p. Janet Cameron, “Word Processing Revisited”, BYTE Guide to the IBM PC, Fall 1. Pages from 1. 98. BYTE> [8] ”Welcome Microsoft Word in A New Version for Windows”, by John Lombardi, Infoworld, January 1. Infoworld_1. 99. 0- 0. Microsoft. Word. Windows. Official PCI Security Standards Council Site. 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AGPM scenario overview. Requirements IIS 7 with ASP.Net and Basic or Windows Authentication installed.Net Framework 3.5 Microsoft SQL Server Compact 4.0 (if using the Group Membership. For this scenario, you will use a separate user account for each role in AGPM to demonstrate how Group Policy can be managed in an environment that has multiple Group Policy administrators who have different levels of permissions.Specifically, you will perform the following tasks: Using an account that is a member of the Domain Admins group, install AGPM Server and assign the AGPM Administrator role to an account or group.Using accounts to which you will assign AGPM roles, install AGPM Client.Using an account that has the AGPM Administrator role, configure AGPM and delegate access to GPOs by assigning roles to other accounts. Group Policy Software Installation Pending Approval On![]() ![]() From an account that has the Editor role, request that a new GPO be created that you then approve by using an account that has the Approver role. Use the Editor account to check the GPO out of the archive, edit the GPO, check the GPO into the archive, and then request deployment. Using an account that has the Approver role, review the GPO and deploy it to your production environment. Using an account that has the Editor role, create a GPO template and use it as a starting point to create a new GPO. Using an account that has the Approver role, delete and restore a GPO. Requirements. Computers on which you want to install AGPM must meet the following requirements, and you must create accounts for use in this scenario. Note. If you have AGPM 2. Windows Server® 2. Windows Server 2. R2 or Windows Server 2. Windows Vista with no service packs installed to Windows 7 or Windows Vista® with Service Pack 1 (SP1), you must upgrade the operating system before you can upgrade to AGPM 4. If you have AGPM 3. AGPM 4. 0. In a mixed environment that includes both newer and older operating systems, there are some limitations to functionality, as indicated in the following table. Windows Server 2. R2 or Windows 7. Windows Server 2. R2 or Windows 7. Supported. Windows Server 2. R2 or Windows 7. Windows Server 2. Windows Vista with SP1. Supported, but cannot edit policy settings or preference items that exist only in Windows Server 2. R2 or Windows 7. Windows Server 2. Windows Vista with SP1. Windows Server 2. R2 or Windows 7. Unsupported. Windows Server 2. Windows Vista with SP1. Windows Server 2. Windows Vista with SP1. Supported, but cannot report or edit policy settings or preference items that exist only in Windows Server 2. R2 or Windows 7. AGPM Server requirements. AGPM Server 4. 0 requires Windows Server 2. R2, Windows Server 2. Windows 7 and the GPMC from Remote Server Administration Tools (RSAT), or Windows Vista with SP1 and the GPMC from RSAT installed. Both 3. 2- bit and 6. Before you install AGPM Server, you must be a member of the Domain Admins group and the following Windows features must be present unless otherwise noted: The following Windows features are required by AGPM Server and will be automatically installed if they are not present: WCF Activation; Non- HTTP Activation. Windows Process Activation Service. Process Model. The . NET Environment. Configuration APIs. AGPM Client requirements. AGPM Client 4. 0 requires Windows Server 2. R2, Windows Server 2. Windows 7 and the GPMC from RSAT, or Windows Vista with SP1 and the GPMC from RSAT installed. Both 3. 2- bit and 6. AGPM Client can be installed on a computer that is running AGPM Server. The following Windows features are required by AGPM Client and unless otherwise noted are automatically installed if they are not present: Scenario requirements. Before you begin this scenario, create four user accounts. During the scenario, you will assign one of the following AGPM roles to each of these accounts: AGPM Administrator (Full Control), Approver, Editor, and Reviewer. These accounts must be able to send and receive e- mail messages. Assign Link GPOs permission to the accounts that have the AGPM Administrator, Approver, and (optionally) Editor roles. Note. Link GPOs permission is assigned to members of Domain Administrators and Enterprise Administrators by default. To assign Link GPOs permission to additional users or groups (such as accounts that have the roles of AGPM Administrator or Approver), click the node for the domain and then click the Delegation tab, select Link GPOs, click Add, and select users or groups to which you want to assign the permission. Steps for installing and configuring AGPMYou must complete the following steps to install and configure AGPM. Step 1: Install AGPM Server. Step 2: Install AGPM Client. Step 3: Configure an AGPM Server connection. Step 4: Configure e- mail notification. Step 5: Delegate access. Step 1: Install AGPM Server. In this step, you install AGPM Server on the member server or domain controller that will run the AGPM Service, and you configure the archive. All AGPM operations are managed through this Windows service and are executed with the service's credentials. The archive managed by an AGPM Server can be hosted on that server or on another server in the same forest. To install AGPM Server on the computer that will host the AGPM Service. Log on with an account that is a member of the Domain Admins group. Start the Microsoft Desktop Optimization Pack CD and follow the instructions on screen to select Advanced Group Policy Management - Server. In the Welcome dialog box, click Next. In the Microsoft Software License Terms dialog box, accept the terms and then click Next. In the Application Path dialog box, select a location in which to install AGPM Server. The computer on which AGPM Server is installed will host the AGPM Service and manage the archive. Click Next. In the Archive Path dialog box, select a location for the archive in relation to the AGPM Server. The archive path can point to a folder on the AGPM Server or elsewhere. However, you should select a location with sufficient space to store all GPOs and history data managed by this AGPM Server. Click Next. In the AGPM Service Account dialog box, select a service account under which the AGPM Service will run and then click Next. This account must be a member of the either the Domain Admins group or, for a least- privilege configuration, the following groups in each domain managed by the AGPM Server: Group Policy Creator Owners. Backup Operators. Additionally, this account requires Full Control permission for the following folders: The AGPM archive folder, for which this permission is automatically granted during the installation of AGPM Server if it is installed on a local drive. The local system temp folder, typically %windir%\temp. In the Archive Owner dialog box, select an account or group to which you assign the AGPM Administrator (Full Control) role. AGPM Administrators can assign AGPM roles and permissions to other Group Policy administrators, so that later you can assign the role of AGPM Administrator to additional Group Policy administrators. For this scenario, select the account to serve in the AGPM Administrator role. Click Next. In the Port Configuration dialog box, type a port on which the AGPM Service should listen. Do not clear the Add port exception to firewall check box unless you manually configure port exceptions or use rules to configure port exceptions. Click Next. 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Harrison County Court at Law Dockets and Schedules.View Harrison County Court at Law jury weeks, daily docket, arraignment dates and docket, mandatory appearance docket, dismissal docket, and probation revocation docket. Scroll down to find docket links on the lower left side of the page.Harrison County District Court Dockets.View Harrison County District Court arraignment docket, pre- trial docket, daily docket call, and probation revocation docket.Scroll down to find docket links on the lower left side of the page.Hays County - Court Dockets Calendars Resources. Hays County Court Calendars. Search Hays County Court District Court, County Court at Law, and Justice of the Peace court calendars by case number, party name, attorney information, judicial officer, or date range. Henderson County - Court Dockets Calendars Resources. Henderson County Court Calendars. Search Henderson County District Court, Constitutional County Court, County Court at Law, and Justice of the Peace court calendars by case number, party name, attorney information, judicial officer, or date range. Hidalgo County - Court Dockets Calendars Resources. Hood County - Court Dockets Calendars Resources. Hood County Court Calendars. Search Hood County District Court and County Court at Law calendars online. Select the "Court Calendar" menu item to begin. Hopkins County - Court Dockets Calendars Resources. Houston County - Court Dockets Calendars Resources. Hutchinson County - Court Dockets Calendars Resources. Jasper County - Court Dockets Calendars Resources. Jefferson County - Court Dockets Calendars Resources. Jefferson County Correctional Facility – Beaumont, TXJefferson County Correctional Facility is in Jefferson County, Texas and is the primary correctional facility for this county. Are you looking for somebody in jail at Jefferson County Correctional Facility? This page gives you information about everything you might need to know about Jefferson County Correctional Facility,like: How to locate an inmate. Find inmate mughsots. The jail’s address and phone number. How to post bail. Booking and intake procedures. Jefferson County court information. And lots more. The prospect of getting arrested and going to jail is a daunting and scary prospect, not only for whoever is incarcerated, but also that person’s family and friends. The purpose of this guide is to give information that you need to make helping a friend or family member get out of jail less stressfull. If you have questions, please feel free to ask them, and any comments or feedback that might be a benefit to others would be appreciated. Address. Jefferson County Correctional Facility. Pearl Street. Beaumont, TX 7. Phone Number and Fax Number. Phone Number: 4. 09- 7. Fax: Inmate Search – Find Out Who’s In Jail. Do you have a family member or friend that is in jail and need to locate them? Has someone that’s been arrested and you don’t know how to find out where they are? To search who’s in jail at Jefferson County Correctional Facility you will have to go to their web site and use the inmate search. The Jefferson County Correctional Facility Inmate List is an online list of persons who have been arrested, which includes status, bail amount (if applicable), and times the inmate can have visitors. You can also find information for anyone arrested and booked or discharged within the past 2. Prisoners are listed alphabetically by last name. You’ll be able to find their arrest information more quickly if you have the arrestee’s first and last name, birth date, or inmate ID Number. If the person you’re searching for might be in another jail you can look here: Other County Jails in Texas. A mugshot, also known as a jail intake picture, is the photograph taken by the police when you are processed at the jail intake. A mugshot is make of one frontal photo and a side photo. Your full name and booking number will appear on the mugshot, and they are stored at the jail. Mugshots of Jefferson County Correctional Facility inmates can be found online, or you can view them at the Jefferson County Correctional Facility. When you search for mugshots on the website you have to enter the name, and the arrest date, if you have one. How To Get Your Mugshot Removed. Want to get your mugshot erased from the Jefferson County Correctional Facility site? This is difficult, because the mugshot is a public record. You will need to file a ‘Petition to Expunge’. Basically, this means that all of your arrest records would be sealed, so no one will be able to see them. Depending on your situation, this may be a longshot. To learn more about removing your mugshot, the various mugshot sites, and the websites that offer to remove your mugshot for you: How To Remove Your Mugshot from the Internet. Return To Main Menu. Bail & Bail Bondsmen – How To Get Out of Jail. Of course, if you’re locked up, your main thought is about getting out. After booking, your bail will be determined by a special judge called a magistrate. If you don’t get a bail set this can mean that you will either be free to go until your trial, or you are kept in jail until your court date. If you are released from jail you are required to promise to go to your court date, and until that date you can’t go out of town. Typically, a prisoner can earn time off for good behavior if they respect the rules and don’t cause any problems while they are in jail. If you follow the rules, you might be allowed to participate in work release. You will either have to stay jail every day when you’re finished working, or you may get to move into a halfway house when you are not working. Your bail is money that you have to pay to the courts to be released from jail pending trial. The amount you will have to pay is dictated by the crime you are charged with. You or someone you know will have to pay 1. If you don’t show up for your scheduled court date, the person that paid your bail will lose that money. Find Out How Much Someone’s Bail Is. To find out how much bail money you will need to bail someone out of jail will have to call the Jefferson County Correctional Facility or the County Courthouse. If you have all the person’s info, including name, address and date of birth, they will be able to let you know the bail amount. Also, you can find out how much their bail is on the Jefferson County Correctional Facility site. How To Bail Someone Out of Jail. Having to get someone out of jail is never fun, but in some cases, it’s easy if you have the money. First, you need to find out if they have a Cash Only Bond. If so, you will not be able to use a bondsman. They only accept cash at the jail, so you have to take cash – they won’t accept checks. When you’ve paid bail, the prisoner will be released. If the conditions of bail are not violated, the bail money you posted will be returned to you. If bail is set too high, of if you can’t pay it, you you should hire a bail bondsman. They will usually charge a fee of 1. The amount you pay to the bondsman will not be returned to you and bondsmen usually only accept cash. If the bail has been set really high, the bail bondsman will in most cases ask to use your personal assets as collateral in addition to the fee they charge. To find a bail bondsman visit our page about: Find a bail bondsman at Jefferson County Correctional Facility. Have you ever had to use a bail bondsman because you or someone you know got arrested? If you have, post a comment below and tell about it, and let us know how it worked out. Click here to leave a comment. Other Ways to Get Out of Jail. Early Release For Good Behavior. Work Release Programs. Time Served. Be Released on a Pre- Trial Release Program. Get Released on House Arrest. Get Released on Your Own Recognizance. Return To Main Menu. Jail Policies and Procedures. Intake Procedures / Booking. The intake procedure is made up of these steps: You will get put in a holding cell. If the jail is really busy, you will have to wait, sometimes for many hours, before you get processed. Firstly, you have to answer a bunch of questions, like your full legal name, home address, birth date and an emergency contact person. They’ll also ask you about your medical and psychological history. You will be issued an inmate number. You will get fingerprinted. You will get your mugshot taken. All personal property will get taken away from you and stored until you get discharged from jail. You will get to use the telephone to talk to a member of your family, friend, or bail bondsman. If you are expected to be released quickly, you might get to keep wearing your own clothes, otherwise you you will have to wear a jail issued jumpsuit. Have you been arrested and gone through jail intake? If so, please share your experience so others can benefit from your story. How long did you have to wait? How did the guards treat you? Can you tell us tips that will help other people make it through the procedure? Click here to comment. Once you are able to post bail, you will be discharged from jail. Getting discharged may take between 3. In other words the faster you can post bail, the faster you will get released. Also, it will depend on whether you’ve got a bond amount or if the magistrate has to figure out the amount of bail to be set. For a minor offense, you will be booked and released on your own recognizance. If you have served a sentence in jail and know the date of your release, plan to get discharged in the morning. In the case of an outstanding warrant, report to the jail intake center, and tell the intake officer that you think they might have a warrant for your arrest. The officer will verify that you have an outstanding arrest warrant, and if there is one, you will be taken into the sheriff’s custody. If you are reporting to serve out your sentence, go down to the jail at the time and date that the sentence order or court paperwork states. Be very careful that you don’t show up late. Only bring things that are allowed when you go to jail, like a driver’s license or even your ID, any prescription medication you might take, as well as the sentencing order from court. ![]()
Partner Perspectives. Partner Perspectives. Partner Perspectives. Computerworld covers a wide range of technology topics, including software, security, operating systems, mobile, storage, servers and data centers, emerging tech, and. InformationWeek.com: News, analysis and research for business technology professionals, plus peer-to-peer knowledge sharing. Engage with our community. RadioSure enables you turn your computer into the farthest reaching radio in the world. From this app, you can listen to radio stations from all across the. WinAvi All in One Converter Crack + Registration Code Full Version is latest professional software designed to convert the all popular video & audio formats. White Papers. Current Issue.Digital Transformation Myths & Truths.Transformation is on every IT organization's to- do list, but effectively transforming IT means a major shift in technology as well as business models and culture. In this IT Trend Report, we examine some of the misconceptions of digital transformation and look at steps you can take to succeed technically and culturally.[Interop ITX 2.State Of Dev. Ops Report.The Dev. Ops movement brings application development and infrastructure operations together to increase efficiency and deploy applications more quickly. ![]() But embracing Dev. Ops means making significant cultural, organizational, and technological changes. This research report will examine how and why IT organizations are adopting Dev. Ops methodologies, the effects on their staff and processes, and the tools they are utilizing for the best results. Video. Sponsored Video. Slideshows. Twitter Feed. Abstracts. President's Plenary Session and Young Investigator's Awards. PPL- 0. 14/2. 0/0. Abstract Numbers 1–7. RNA STABILITY REGULATES DIFFERENTIAL EXPRESSION OF THE METASTASIS PROTEIN, OSTEOPONTIN, IN HEPATOCELLULAR CANCERSirisha Emani, Ph. D, Jinping Zhang, MD, Ph. D, Luci Guo, Hongtao Guo, MD, Ph. D, Paul C Kuo, MDDuke Univ Med Ctr, Durham, NCIntroduction. Osteopontin (OPN) is a potential therapeutic target in hepatocellular cancer (HCC) as it is a critical mediator of metastatic function. OPN antibody blocks HCC cell invasion in vitro and inhibits pulmonary metastasis in vivo. However, the molecular mechanisms which determine expression of OPN in HCC are largely unknown. In this study, we examine differential OPN expression in Hep. G2 (high OPN) and Hep. B (low OPN) HCC cell lines. دانلود بازی Call of Duty Modern Warfare Remastered برای PC دانلود بازی ندای وظیفه 4: جنگاوری مدرن نسخه جدید. دانلود بازی Sid Meiers Civilization VI Proper برای PC دانلود بازی Sid Meiers Civilization VI برای کامپیوتر بازی تمدن. SpringerPlus journal page at PubMed Journals. Published by SpringerPlus. ![]() ![]() We would like to show you a description here but the site won’t allow us. ----- Important Microsoft Bulletins & Security Patches Version : 0.3 Date : 21/12/2011. Methods. OPN protein was measured with Western blots; Northern blots determined steady state OPN m. RNA levels. Chromatin immunoprecipitation assays (Ch. IP) for RNA pol. 2 at the OPN promoter measured transcription. Actinomycin D (1. M) was used to inhibit transcription. Transient transfection analysis used the full length human OPN promoter (2. In vitro decay analysis measured OPN m. RNA decay relative to the poly (A) tail. The contribution of OPN 3′- UTR (4. UTR (1. 70 bp) was determined by transient transfection of luciferase- 3′UTR or 5′- UTR- luciferase constructs in p. GL3 promoter vector following excision of the SV4. A) signal; luciferase m. RNA determined differences in RNA degradation. RNA gelshift assays measured extent and patterns of protein binding to OPN 5′- UTR. Data are expressed as mean±SEM; analysis was performed with the Students t test.)Results. Hep. G2 OPN protein in cell lysate and medium was 1. Hep. 3B (p < 0. Similarly, OPN m. RNA was 7- fold greater in Hep. G2 cells (p < 0. Hep. 3B). However, transfection of the OPN promoter demonstrated equivalent luciferase activities in the two cell lines; the rate of transcription was also equivalent as determined by Ch. IP. OPN m. RNA half life was 6. Hep. G2 and Hep. 3B, respectively (p < 0. RNA stability is regulated by the poly (A) tail, 5′- UTR or 3′- UTR. In Hep. G2 and Hep. B, nucleotide sequence of OPN and its 5′- UTR and 3′- UTR were identical between. The poly (A) tails were also equivalent in length and did not impact OPN m. RNA stability. Luciferase m. RNA coupled with OPN- 5′- UTR was 6- fold higher in the Hep. G2 cells (p < 0. Hep. 3B); 3′UTR did not alter OPN m. RNA expression. RNA gelshift assays demonstrate differing protein binding patterns to 5″- UTR between the 2 cell lines. Conclusion. In Hep. G2 and Hep. 3B, different repertoires of RNA binding proteins targeting OPN 5′- UTR regulate OPN m. RNA stability and alter OPN expression. We conclude that RNA stability is one mechanism which regulates OPN expression in HCC to convey metastatic function. This has not been previously described for OPN regulation in any setting. ATTENUATEDLISTERIASTRAINS DEPLETED OF REGULATORY T CELLS EFFECTIVELY TARGET HEPATIC COLORECTAL METASTASESKiyoshi Yoshimura, MD, Ph. D, Lindsay Sue Laird, None, Kristen Faith Meckel, None, Drew Mark Pardoll, MD, Ph. D, Richard David Schulick, MDJohns Hopkins Medical Institutions, Baltimore, MDBackground and Objectives.The liver represents a major and frequently sole site of metastases for many types of cancer, particularly gastrointestinal cancers. Here we demonstrate that administration of multiple doses of an engineered hepatic targeting Listeria monocytogenes (LM) generates therapeutic responses against hepatic metastases.LM treatment of mice bearing hepatic metastases induced tumor- specific CD8 responses that were enhanced by depletion of regulatory T cells either by anti- CD2.Cytoxan treatment.Antitumor activity of LM was dependent on the presence of NK cells but was inhibited by the presence of NKT cells. Methods. BALB/c mice were challenged with 1.CT2. 6 (syngeneic colorectal cancer cells) in an isolated hepatic metastasis model. Three days after tumor challenge, the mice were inititiated on a course of intraperitoneal injections of attenuated strains of LM (at 1/1.LD5. 0) for three doses three days apart. Survival was followed and immune cells were analyzed for phenotype, activation status, and effector function. Depletions of key subsets of immune effectors was performed to analyze effect. Results. LM treatment provided a significant survival advantage which was greatly enhanced by depletion of CD2. T cells. (See Figure). Furthermore depletion of CD8+ T cells abrogated the survival advantage of LM and depletion of CD4+ T cells was intermediate in effect. Conclusions. These results demonstrate the utility of LM in the treatment of hepatic metastases and further suggest that blockade of regulatory T cells will enhance anti- tumor activity. TREATMENT OF UNRESECTABLE CHOLANGIOCARCINOMA WITH GEMCITABINE- BASED TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION (TACE): SINGLE- INSTITUTION EXPERIENCENiraj Gusani, MD, Fady Balaa, MD, Jennifer Steel, MD, David A Geller, MD, Wallis Marsh, MD, Brain Carr, MD, Ph. D, T. Clark Gamblin. UPMC Liver Cancer Center, University of Pittsburgh, Pittsburgh, PABackground. Survival for patients with unresectable cholangiocarcinoma is reported to be only 5–8 months. Systemic chemotherapy has been disappointing and not shown to significantly improve survival. Transcatheter arterial chemoembolization (TACE) has been shown to prolong survival in hepatocellular carcinoma patients but experience with cholangiocarcinoma is limited. We report our experience with TACE using chemotherapeutic regimens based on the well- tolerated drug gemcitabine. Methods. Forty- two patients with unresectable cholangiocarcinoma were treated with one or more cycles of gemcitabine- based TACE (2. Follow- up imaging was performed on all patients after each TACE procedure. Regimens of TACE included: gemcitabine only (1. Actual survival is reported, as 4. Results. Patients were 5. Median survival from time of first treatment was 9. Patients receiving gemcitabine followed by cisplatin or oxaliplatin had improved survival (median 1. Patients receiving gemcitabine and cisplatin as a combination also had improved survival (median 1. Patients who progressed on gemcitabine and cisplatin and then received oxaliplatin also showed improved survival (median 1. Neutropenia, thrombocytopenia and hyperbilirubinemia were the most common toxicities observed. Three patients in the entire series exhibited grade 3 thrombocytopenia while seven patients had grade 3 and one had grade 4 elevation of bilirubin levels. Conclusions. Our report represents the largest series to date regarding hepatic artery directed therapy for unresectable cholangiocarcinoma and provides evidence in favor of TACE rather than historically reported alternatives such as systemic chemotherapy or chemotherapy/RT. Our results suggest that gemcitabine based TACE is well- tolerated and with seemingly better survival when given in combination therapy for patients with unresectable cholangiocarcinoma. PANCREATIC TRANSECTION MARGIN AT THE TIME OF PANCREATICODUODENECTOMY: CLINICAL IMPLICATIONS OF A POSITIVE MARGINCurtis J Wray, MD, Henry F Gomez, MD, Jean Nicholas Vauthey, MD, Eddie K Abdalla, MD, Jeffrey E Lee, MD, Huamin Wang, MD,Ph. D, Douglas B Evans, MD, Peter Wt Pisters. Houston, Center, Cancer Anderson MD Texas of University. Introduction. The pancreatic transection margin (PM) is often submitted for frozen section when performing pancreaticoduodenectomy for adenocarcinoma to allow re- resection if the PM is positive. However, the natural history of patients with an initially positive PM is not well defined and therefore, there are no clear guidelines for the performance of a frozen section or the management of a positive PM. Methods. The pancreatic cancer database was queried for all patients with pancreatic adenocarcinoma who underwent pancreaticoduodenectomy. Patients with cystic neoplasms (including IPMN) were excluded. Pathology and operative reports were re- reviewed to verify margin status. Patients were classified based on the status of the PM as: Group 1: negative initial frozen section; Group 2: negative after re- resection of a positive PM; and Group 3: positive margin. Results. PD was performed on 3. PA from 1. 99. 0 to 2. Of the remaining 3. PM was negative on intraoperative frozen section in 3. Of the 3. 09 Group 1 patients, permanent pathology review confirmed a negative PM in 3. All 4. 5 patients with a positive intraoperative margin underwent re- resection; 4. Games. Radar+Games. Radar+ is part of Future plc, an international media group and leading digital publisher. Wasted money on unreliable and slow multihosters?LinkSnappy is the only multihost that works.Download from ALL Filehosts as a premium user at incredibly fast speeds!The fables of Fable continue to be told with this third series. Download Games Torrents for PC, XBOX 360, XBOX.Red Dead Redemption 2 Xbox One Torrent.
News, reviews, previews, tips, and downloads for multiple platforms.Visit our corporate site.©. Future Publishing Limited. Quay House, The Ambury. Bath. BA1 1. UA. All rights reserved. England and Wales company registration number 2. ![]() PC - Skidrow Games - Crackheyi’d just like to name a few games that i’d really like to see uploaded with crack pc versions. Not entirely sure if some are possible but here goes: -Metal Gear Solid (i love all parts!)- Devil may cry 3 or 4- hmm. I noticed the uploaded arcade versions, i grew up playing those and have played like, every MK game that came out except ps. Marvel vs Capcom 3? PLS, this is a HUGE request with blueberry cheesecake on top, PLS upload atleast something from the Final Fantasy games. Oddworld: Abe’s Exodus. One of my favs back when i had a ps. P just a suggestion. |
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